New Molecular Solutions in Research and Development for Innovative Drugs

Timeline

The detailed schedule for the workshop.

Day 1 (June 1, 2015) Day 2 (June 2, 2015) Day 3 (June 3, 2015)

9:30-13:00 Registration

10:30-10:45 Opening by Oliver Vugrek, Project Coordinator

Morning session (chair: Ivo Piantanida)

10:45-11:45 Frank Würthner: Self-assembly of Perylene Dyes in Water and Interactions with DNA and RNA

Morning session (chair: Nikola Basarić)

10:00-10:45 Dr. Raúl Pacheco-Gómez: Microcalorimetry: A versatile tool for the characterization of biomolecular interactions

10:45-11:15 Coffee/tea break

11:15-12:00 Jurij Lah: What drives DNA folding into G-quadruplex structures and their recognition by ligands?

Hands-on workshop
Two groups:

9:00-9:30 Seminar room 1: ITC/DSC Introduction

9:00-9:30 Seminar room 2: CD/LD Introduction  

1st Group:

CD/LD spectropolarimetry:
a) DNA and protein structure characterisation
b) Study of DNA/protein/ligand interaction – affinity, kinetics, structural aspects of complexes
Viscometry: Ligand binding mode impact on viscosity of biomacromolecule solution

2nd Group

Microcalorimetry:
a)    ITC: binding affinity, kinetics
b) PEAQ-ITC innovations
c)    DSC: structural characterisation

12.00-13.30 Lunch break

(with the compliments of the Organizing Committee)

12:00-13:30 Lunch break

(with the compliments of the Organizing Committee)

12:00-13:00 Lunch break

(with the compliments of the Organizing Committee)

Afternoon session (chair: Ivo Piantanida)

13:30-14:30 Carsten Schmuck: Pros and Cons of H-bonds, ion-pairing and other electrostatic interactions (Part I)

14:30-15:00 Coffee/tea break

15:00-15:30 Carsten Schmuck (Part II)

 

Afternoon session (chair: M. Abramić)

13:30-14:30 Peter Macheroux: Applications of Microcalorimetry to Biomolecular Interactions

14:30-14:45 Coffee/tea break
Afternoon session (chair: Marin Roje)

14:45-15:15 Andreas Benkö (ABL&E GmbH, Wien): Circular Dichroism Spectrometry: Basics, Instrumental Developments and Application Examples

15:15-16:15 Gennaro Pescitelli: Exciton-coupled CD spectroscopy in the study of supramolecular systems: functional polymers, organogels, retinylidene proteins.
Open discussion/closing remarks

13:30 Introduction  

2nd Group

CD/LD spectropolarimetry:

a) DNA and protein structure characterisation

b) Study of DNA/protein/ligand interaction – affinity, kinetics, structural aspects of complexes

Viscometry: Ligand binding mode impact on viscosity of biomacromolecule solution

1st Group

MIcrocalorimetry:

a)              ITC: binding affinity, kinetics

b) PEAQ-ITC innovations

c) DSC: structural characterisation