New Molecular Solutions in Research and Development for Innovative Drugs

Differential scanning calorimeter (DSC)

The Nano differential scanning calorimeter (Nano DSC) is specifically designed to determine the thermal stability and heat capacity of proteins and other macro-molecules in dilute solution, with the versatility and precision to perform molecular stability screening, ligand binding and pressure perturbation measurements.

The Nano DSC is designed to measure the amount of heat absorbed or released by dilute in-solution bio-molecules as they are heated or cooled.

Macromolecules such as proteins respond to heating or cooling by unfolding at a characteristic temperature. The more intrinsically stable the biopolymer, the higher the midpoint temperature of the unfolding transition.

Nano DSC Specifications:  
Short-term Noise: 0.015 μWatts
Baseline Stability: ±0.028 μWatts
Response Time: 7 seconds
Operating Temperature: -10 °C to 130 °C or 160 °C
Temperature Scan Rate: 0.05 °C to 2°C/minute
Pressurization Perturbation: Built-in up to 6 atmospheres
Cell Volume: 0.30 ml
Cell Geometry: Fixed capillary
Cell Composition: Platinum
Heat Measurement Type: Power Compensation

Analytics (DSC)